Among papers with data figures, 47.7% of papers used bar graphs to present continuous data. We conducted a systematic review of studies published in top peripheral vascular disease journals to determine what types of figures are used, and to assess the prevalence of suboptimal data visualization practices. These policies encourage authors to avoid bar graphs and use graphics that show the data distribution however, they provide little guidance on how to effectively display data. Reports highlighting the problems with the standard practice of using bar graphs to show continuous data have prompted many journals to adopt new visualization policies. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).

Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).Collectively, our data show that besides naive T cells proliferation, MYC is essential for effector/memory differentiation. In contrast, we uncovered that Myc ablation in CD4 +CD8 + thymocytes disrupts T lymphocytes homeostasis in the spleen, notably by drastically reducing the number of MYC-deficient effector/memory T cells. First, our results confirm that MYC is mandatory for PTEN loss-mediated leukemogenesis, while it is not required for terminal steps of thymopoiesis. Herein, we used conditional Pten and Myc knockout mouse models and single-cell RNA-sequencing approach, to investigate the impact of MYC loss on physio-pathological development of PTEN-proficient or PTEN-deficient T lymphocytes. Among recurrent alteration is PTEN inactivation, which is associated to MYC overexpression.

During thymopoiesis, genomic alterations in thymocytes can promote leukemia development. In the thymus, T cell progenitors differentiate in order to generate naive T lymphocytes which migrate in the periphery where they will fulfill their function in the adaptive immune response.

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